The film follows a seemingly usual day in the life of Loida Malabanan as she embarks on yet another shooting day of a soap opera as an extra. As the shoot goes on, we get a glimpse of the truth in the ruling system of the production as well as the exploitation of the marginalized laborers like her

Shirley Templo is a ruthless woman. Many people deal with her strong attitude only for fear of her cold stare, or her outlash. She works as a librarian in a school, and lives in a compound that is owned by her ex-husband, Benito Salvacion. Many of the Salvacion family members that live near the compound, even including her eldest daughter, Dang, plead with her to sell it so they can make a profit, and she can move to a more suitable living area. Hard-headed as she is, Shirley refuses and feels betrayed by her two daughters, Dang and Cherry, for even siding with their father who left them nearly fifteen years ago. Even more upset, she finds out that Dang will want to move out of the Philippines to Australia. Leaving her alone in the Philippines since all her children moved out, Shirley decides to move to New York City with her youngest and only son, Mark Salvacion. Mark is unaware, however, that this supposed vacation of his mother is actually a permanent visit.
Upon her arrival to the States, Shirley is picked up at the airport by Noel Villanueva. Thinking he was only hired help, she rudely offers him payment for his services, but he declines. As she walks around the apartment, she notices pictures of Mark and Noel being affectionate toward each other. She then realizes that Noel is, in fact, Mark's new boyfriend. Although she was aware of Mark's homosexuality since his high school years, she gives Noel plenty of trouble and hard times. The story reflects how Shirley changes her attitudes and views from two men that become a big part of her life, and how she accepts the reality that has been presented to her. Unfortunately, unforeseen tragedies occur, and a rift between Shirley and Noel arise. But as she understands Mark's reasons for having her be around Noel all this time, she resolves her issues with him and soon embraces him as a member of her family.

Vivian, a successful businesswoman, learns that she is suffering from stage 3 cancer, and hires a private nurse, Jaica to take care of her. But Jaica begins to play a bigger role in Vivian's life as she becomes the bridge between Vivian and her son, Albert who has felt neglected all his life. The three change and are changed by their circumstances?

A young man hires a woman to play his bride to get his inheritance. As the ruse goes on, feelings develop between them.

An ugly duckling girl, Sandy, is left heartbroken by her boyfriend. Soon after, she meets her new boss Alex. He promises to help her in exchange for her helping him save his grandfather's company. Along the way, she becomes someone who's worth loving.

Jane, a die-hard fan, wants to win tickets to Billy Fernandez's concert. To do this she must answer the question, "What would you do if it was the end of the world?" In search for this answer she meets different people with different love stories: a 40-year-old virgin named Virginia (Pokwang) who meets a gigolo named Charles; a hopeless romantic secretary, Barbara who is helping her boss, Ken with "personal issues"; Belle who is in love with her gay best-friend, Butch, an advertising executive; Verna who falls in love with Jane's older brother, Elvis, a waiter in Vietnam; Jomar an orphan who is trying to court Ayie with the help of a 35-year-old mentally-challenged man named Pipoy; Patty who traces her first love, Alvin to become an underwear model for her company.

Segment: Emergency
Jay and Dr. Sarah face the wrath of an aswang (vampire/fleash-eating witch).

Segment: Class Picture
A mysterious class picture with bloody writing on it is found in the school's storage room.

Segment: Nieves
Follows the engkanto (forest spirit) slayer Nieves.

Mae and Bogs' long time friendship gets tested when Bogs gets dumped by his girlfriend and Mae finally admits she's in love with him. The two get into a relationship but Mae fears this is only Bogs' way of dealing with his previous heartache.

Awarded radio personality George Harrison Apostol, known as DJ Heidee to her listeners, provides love advice to people who are having problems in their relationships. DJ Heidee receives a call from a girl named Melissa who is asking advice on how to break up with her boyfriend Andrew. Unfortunately, Andrew is listening to the same program and hears Heidee telling Melissa how they should break up. Andrew blames Heidee for what happened and even threatens to sue her for giving that particular advice. In order to prevent a legal battle, and to ease her conscience, Heidee decides to help Andrew win Melissa back. In the process of getting the two together, Andrew and Heidee begin to feel an attraction toward each other. Will they be able to overcome their past and become lovers instead?

Roanne Sanchez, a young girl with high ideals about romance is assigned to accompany the spoiled son of the president, Eric Rodriguez as he goes on an immersion trip. Coming from different worlds, the two find much to fight about, but sudden attraction between then soon gets the better of them.

Segment: Emergency
Jay and Dr. Sarah face the wrath of an aswang (vampire/fleash-eating witch).

Segment: Class Picture
A mysterious class picture with bloody writing on it is found in the school's storage room.

Segment: Nieves
Follows the engkanto (forest spirit) slayer Nieves.

Mae and Bogs' long time friendship gets tested when Bogs gets dumped by his girlfriend and Mae finally admits she's in love with him. The two get into a relationship but Mae fears this is only Bogs' way of dealing with his previous heartache.